研究論文

これまでに弊社の研究員が発表した研究論文(抜粋)の一覧表です。

題名 掲載誌名 著者
Generation of Various Telencephalic Regions from Human Embryonic Stem Cells in Three-Dimensional Culture Methods Mol Biol. 2017;1597:1-16. Kadoshima T, Sakaguchi H, Eiraku M.
Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus Arthritis Res Ther. 2017 Mar 14;19(1):58. Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, Takasaki Y, Miyake S.
Discovery and dimeric approach of novel Natriuretic Peptide Receptor A (NPR-A) agonists Bioorg Med Chem. 2017 Mar 15;25(6):1762-1769. Epub 2017 Jan 28. Iwaki T, Oyama Y, Tomoo T, Tanaka T, Okamura Y, Sugiyama M, Yamaki A, Furuya M.
Ecrg4 contributes to the anti-glioma immunosurveillance through type-I interferon signaling Oncoimmunology. 2016 Oct 14;5(12):e1242547. Moriguchi T, Kaneumi S, Takeda S, Enomoto K, Mishra SK, Miki T, Koshimizu U, Kitamura H, Kondo T.
Guanylate-binding protein 5 is a marker of interferon-γ-induced classically activated macrophages Clin Transl Immunology. 2016 Nov 2;5(11):e111. Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y.
Incomplete KLK7 Secretion and Upregulated LEKTI Expression Underlie Hyperkeratotic Stratum Corneum in Atopic Dermatitis J Invest Dermatol. 2017 Feb;137(2):449-456. Igawa S, Kishibe M, Minami-Hori M, Honma M, Tsujimura H, Ishikawa J, Fujimura T, Murakami M, Ishida-Yamamoto A.
The dynamics of mucosal-associated invariant T cells in multiple sclerosis Springerplus. 2016 Aug 5;5(1):1259. doi: 10.1186/s40064-016-2923-9. eCollection 2016. Sugimoto C, Hirotani M, Yoshikiyo K, Koshimizu U, Wakao R, Horinouchi T, Mazaki Y, Higashi T, Fukazawa T, Fujita H, Sasaki H, Wakao H.
Hepatocyte Nuclear Factor-1beta Induces Redifferentiation of Dedifferentiated Tubular Epithelial Cells PLoS One. 2016 May 19;11(5):e0154912. doi: 10.1371/journal.pone.0154912. eCollection 2016. Omata M, Doke Y, Yamada C, Kawashima K, Sho R, Enomoto K, Furuya M, Inomata N.
A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice J Radiat Res. 2016 Sep;57(5):567-571. Epub 2016 May 29. Nakagami Y, Masuda K.
ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease J Pharmacol Exp Ther. 2016 Mar;356(3):604-14. doi: 10.1124/jpet.115.229906. Epub 2015 Dec 23. Kanai S, Ishihara K, Kawashita E, Tomoo T, Nagahira K, Hayashi Y, Akiba S.
Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma Sci Rep. 2016 Feb 9;6:20473. doi: 10.1038/srep20473. Fujikawa A, Nagahira A, Sugawara H, Ishii K, Imajo S, Matsumoto M, Kuboyama K, Suzuki R, Tanga N,, Noda M, Uchiyama S,, Tomoo T, Ogata A, Masumura M, Noda M,
Des-acyl ghrelin prevents heatstroke-like symptoms in rats exposed to high temperature and high humidity Neurosci Lett. 2016 Feb 26;615:28-32. doi: 10.1016/j.neulet.2016.01.003. Epub 2016 Jan 8. Inoue Y, Hayashi Y, Kangawa K, Suzuki Y, Murakami N, Nakahara K.
Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner BMC Med Genomics. 2015 Dec 18;8:82. doi: 10.1186/s12920-015-0158-1. Hizukuri Y, Sawada R, Yamanishi Y,.
Structural Optimization of Ghrelin Receptor Inverse Agonists to Improve Lipophilicity and Avoid Mechanism-Based CYP3A4 Inactivation Chem Pharm Bull (Tokyo). 2015;63(10):825-32. doi: 10.1248/cpb.c15-00285. Takahashi B, Funami H, Shibata M, Maruoka H, Koyama M, Kanki S, Muto T.
Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model J Pharmacol Exp Ther. 2015 Sep;354(3):440-7. doi: 10.1124/jpet.115.225391. Epub 2015 Jul 2. Nakajima M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M
Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model Bioorg Med Chem. 2015 Aug 1;23(15):4792-803. doi: 10.1016/j.bmc.2015.05.047. Epub 2015 Jun 9. Takahashi B, Funami H, Iwaki T, Maruoka H, Shibata M, Koyama M, Nagahira A, Kamiide Y, Kanki S, Igawa Y, Muto T.
2-Aminoalkyl nicotinamide derivatives as pure inverse agonists of the ghrelin receptor Bioorg Med Chem Lett. 2015 Jul 1;25(13):2707-12. doi: 10.1016/j.bmcl.2015.04.040. Epub 2015 May 1. Takahashi B, Funami H, Iwaki T, Maruoka H, Nagahira A, Koyama M, Kamiide Y, Matsuo T, Muto T, Annoura H.
Cellular uptake and in vivo distribution of polyhistidine peptides J Control Release. 2015 Jul 28;210:115-24. doi: 10.1016/j.jconrel.2015.05.268. Epub 2015 May 14. Iwasaki T, Tokuda Y, Kotake A, Okada H, Takeda S, Kawano T, Nakayama Y.
VGF and striatal cell damage in in vitro and in vivo models of Huntington's disease Pharmacol Res Perspect. 2015 Jun;3(3):e00140. doi: 10.1002/prp2.140. Epub 2015 May 4. Noda Y, Shimazawa M, Tanaka H, Tamura S, Inoue T, Tsuruma K, Hara H
Quantitative analysis of cadherin-11 and beta-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells J Pharm Pharmacol. 2015 Aug;67(8):1075-82. doi: 10.1111/jphp.12410. Epub 2015 Mar 18. Yoshioka R, Kita Y, Nagahira A, Manno A, Makita N, Tomita U, Murakawa M.
Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats Eur J Pharmacol. 2015 May 15;755:88-94. doi: 10.1016/j.ejphar.2015.02.049. Epub 2015 Mar 11. Kamiide Y, Inomata N, Furuya M, Yada T.
Chronic exposure to cigarette smoke causes extrapulmonary abnormalities in rats Environ Toxicol Pharmacol. 2015 Mar;39(2):864-70. doi: 10.1016/j.etap.2015.02.016. Epub 2015 Mar 4. Kamiide Y, Furuya M, Inomata N, Yada T.
IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration. Int Immunol. 2015 Mar;27(3):131-41. doi: 10.1093/intimm/dxu090. Epub 2014 Sep 29. Makita N, Hizukuri Y, Yamashiro K, Murakawa M, Hayashi Y.
SUN11602-induced hyperexpression of calbindin D-28k is pivotal for the survival of hippocampal neurons under neurotoxic conditions Brain Res. 2015 Jan 12;1594:71-81. doi: 10.1016/j.brainres.2014.10.066. Epub 2014 Nov 6. Murayama N, Noshita T, Ogino R, Masuda T, Kadoshima T, Oka T, Ueno N, Takemoto N, Toba T, Ueno S, Schulze W, Igawa Y, Morita Y, Inoue T
Effect of nicotine on neuronal dysfunction induced by intracerebroventricular infusion of amyloid-beta peptide in rats Eur Rev Med Pharmacol Sci. 2015;19(2):334-43. Noshita T, Murayama N, Nakamura S.
Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice. Eur J Pharmacol. 2014 Nov 15;743:1-10. doi: 10.1016/j.ejphar.2014.09.025. Epub 2014 Sep 23. Tsubouchi H, Yanagi S, Miura A, Matsumoto N, Kangawa K, Nakazato M.
SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer׳s disease induced by amyloid β and excitatory amino acids. Brain Res. 2014 Oct 17;1585:159-66. doi: 10.1016/j.brainres.2014.08.023. Epub 2014 Aug 15. Ogino R, Murayama N, Noshita T, Takemoto N, Toba T, Oka T, Narii N, Yoshida S, Ueno N, Inoue T.
Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl) propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors. J Med Chem. 2014 Sep 11;57(17):7244-62. doi: 10.1021/jm500494y. Epub 2014 Aug 26. Tomoo T, Nakatsuka T, Katayama T, Hayashi Y, Fujieda Y, Terakawa M, Nagahira K.
Protective effect of SUN N8075, a radical scavenger, in excessive light-induced retinal damage in mice Biol Pharm Bull. 2014;37(3):424-30. Ojino K, Shimazawa M, Ohno Y, Otsuka T, Tsuruma K, Hara H.
Organ-specific activation of the gastric branch of the efferent vagus nerve by ghrelin in urethane-anesthetized rats J Pharmacol Sci. 2014;124(1):31-9. Epub 2013 Dec 21. Habara H, Hayashi Y, Inomata N, Niijima A, Kangawa K.
In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver Xenobiotica. 2014 Jan;44(2):154-63. doi: 10.3109/00498254.2013.865857. Epub 2013 Dec 4. Igawa Y, Fujitani T, Shah B, Oo C, Kanai Y.
Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design Bioorg Med Chem. 2013 Jul 15;21(14):4233-49. doi: 10.1016/j.bmc.2013.04.079. Epub 2013 May 9. Tanaka T, Sugawara H, Maruoka H, Imajo S, Muto T.
Inflammation and resolution are associated with upregulation of fatty acid beta-oxidation in zymosan-induced peritonitis. PLoS One. 2013 Jun 11;8(6):e66270. doi: 10.1371/journal.pone.0066270. Print 2013. Fujieda Y, Manno A, Hayashi Y, Rhodes N, Guo L, Arita M, Bamba T, Fukusaki E.
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