これまでに弊社の研究員が発表した研究論文(抜粋)の一覧表です。

題名 掲載誌名 著者
Expansion of Functional Human Mucosal-Associated Invariant T Cells via Reprogramming to Pluripotency and Redifferentiation. Cell Stem Cell. 2013 May 2;12(5):546-58. doi: 10.1016/j.stem.2013.03.001. Epub 2013 Mar 21 Wakao H, Yoshikiyo K, Koshimizu U, Furukawa T, Enomoto K, Matsunaga T, Tanaka T, Yasutomi Y, Yamada T, Minakami H, Tanaka J, Oda A, Sasaki T, Wakao R, Lantz O, Udagawa T, Sekiya Y, Higuchi K, Harada N, Nishimura K, Ohtaka M, Nakanishi M, Fujita H.
Availability of a microglia and macrophage marker, iba-1, for differential diagnosis of spontaneous malignant reticuloses from astrocytomas in rats. J Toxicol Pathol 2013 Mar;26(1):55-60. doi: 10.1293/tox.26.55. Epub 2013 Apr 22 Nakamura R, Nishimura T, Ochiai T, Nakada S, Nagatani M, Ogasawara H.
SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. ACS Chem Neurosci. 2013 Feb 20;4(2):266-76. doi: 10.1021/cn300183k. Epub 2012 Nov 21. Murayama N, Kadoshima T, Takemoto N, Kodama S, Toba T, Ogino R, Noshita T, Oka T, Ueno S, Kuroda M, Shimmyo Y, Morita Y, Inoue T.
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. 2013 Jan 3;12(1):127-37. doi: 10.1016/j.stem.2012.09.013. Epub 2012 Nov 15 Tohyama S, Hattori F, Sano M, Hishiki T, Nagahata Y, Matsuura T, Hashimoto H, Suzuki T, Yamashita H, Satoh Y, Egashira T, Seki T, Muraoka N, Yamakawa H, Ohgino Y, Tanaka T, Yoichi M, Yuasa S, Murata M, Suematsu M, Fukuda K.
Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet. J Lipid Res. 2013 Jan;54(1):85-96. doi: 10.1194/jlr.M029017. Epub 2012 Oct 17 Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y.
Central and peripheral des-acyl ghrelin regulates body temperature in rats. Biochem Biophys Res Commun. 2013 Jan 4;430(1):278-83. doi: 10.1016/j.bbrc.2012.10.137. Epub 2012 Nov 15 Inoue Y, Nakahara K, Maruyama K, Suzuki Y, Hayashi Y, Kangawa K, Murakami N.
Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination. PLoS One. 2012;7(11):e48797. doi: 10.1371/journal.pone.0048797. Epub 2012 Nov 7. Kuboyama K, Fujikawa A, Masumura M, Suzuki R, Matsumoto M, Noda M.
Effect of bFGF on neuronal damage induced by sequential treatment of amyloid β and excitatory amino acid in vitro and in vivo. Eur J Pharmacol. 2012 Nov 15;695(1-3):76-82. doi: 10.1016/j.ejphar.2012.09.020. Epub 2012 Sep 28. Noshita T, Murayama N, Oka T, Ogino R, Nakamura S, Inoue T.
Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice. Regul Pept. 2012 Oct 10;178(1-3):21-8. doi: 10.1016/j.regpep.2012.06.003. Epub 2012 Jun 28. Sugiyama M, Yamaki A, Furuya M, Inomata N, Minamitake Y, Ohsuye K, Kangawa K.
Synthesis of ghrelin: chemical synthesis and semisynthesis for large-scale preparation of modified peptides. Methods Enzymol. 2012;514:183-203. doi: 10.1016/B978-0-12-381272-8.00012-X Makino T, Matsumoto M, Minamitake Y.
Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli. Metab Eng. 2012 Sep;14(5):591-602. doi: 10.1016/j.ymben.2012.05.001. Epub 2012 May 17 Skretas G, Makino T, Varadarajan N, Pogson M, Georgiou G.
Metabolite profiles correlate closely with neurobehavioral function in experimental spinal cord injury in rats. PLoS One. 2012;7(8):e43152. doi: 10.1371/journal.pone.0043152. Epub 2012 Aug 13 Fujieda Y, Ueno S, Ogino R, Kuroda M, Jönsson TJ, Guo L, Bamba T, Fukusaki E.
In vitro selection of a peptide antagonist of growth hormone secretagogue receptor using cDNA display. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11121-6. doi: 10.1073/pnas.1203561109. Epub 2012 Jun 20. Ueno S, Yoshida S, Mondal A, Nishina K, Koyama M, Sakata I, Miura K, Hayashi Y, Nemoto N, Nishigaki K, Sakai T.
Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. Bioorg Med Chem. 2012 May 1;20(9):2850-9. doi: 10.1016/j.bmc.2012.03.025. Epub 2012 Mar 20 Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H.
Possible involvement of melanocortin-4-receptor and AMP-activated protein kinase in the interaction of glucagon-like peptide-1 and leptin on feeding in rats. Biochem Biophys Res Commun. 2012 Mar 30;420(1):36-41. doi: 10.1016/j.bbrc.2012.02.109. Epub 2012 Feb 27 Poleni PE, Akieda-Asai S, Koda S, Sakurai M, Bae CR, Senba K, Cha YS, Furuya M, Date Y.
A new strategy for metabolic stabilization of motilin using the C-terminal part of ghrelin. Peptides. 2012 Feb;33(2):279-84. doi: 10.1016/j.peptides.2012.01.010. Epub 2012 Jan 23 Morozumi N, Sato S, Yoshida S, Yamaki A, Furuya M, Inomata N, Ohnuma N, Minamitake Y, Ohsuye K, Kangawa K.
The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice. Biomaterials. 2012 Jan;33(1):317-24. doi: 10.1016/j.biomaterials.2011.09.048. Epub 2011 Oct 7. Suzuki H, Kondoh M, Kakutani H, Yamane S, Uchida H, Hamakubo T, Yagi K.
Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients. Int Immunopharmacol. 2011 Oct;11(10):1628-32. doi: 10.1016/j.intimp.2011.05.025. Epub 2011 Jun 12. Ogata A, Fujieda Y, Terakawa M, Muto T, Tanaka T, Maruoka H, Nagahira K, Fukuda Y, Tomimori Y, Watanabe N.
Mutated C-terminal fragments of Clostridium perfringens enterotoxin have increased affinity to claudin-4 and reversibly modulate tight junctions in vitro. Biochem Biophys Res Commun. 2011 Jul 8;410(3):466-70. doi: 10.1016/j.bbrc.2011.05.161. Epub 2011 Jun 6 Takahashi A, Kondoh M, Uchida H, Kakamu Y, Hamakubo T, Yagi K.
The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in rats. Peptides. 2011 May;32(5):1001-7. doi: 10.1016/j.peptides.2011.01.021. Epub 2011 Feb 1 Morozumi N, Hanada T, Habara H, Yamaki A, Furuya M, Nakatsuka T, Inomata N, Minamitake Y, Ohsuye K, Kangawa K.
Effects of piclozotan (SUN N4057), a partial serotonin 1A receptor agonist, on motor complications induced by repeated administration of levodopa in parkinsonian rats. Eur J Pharmacol. 2010 Dec 15;649(1-3):218-23. doi: 10.1016/j.ejphar.2010.09.013. Epub 2010 Sep 19 Tani Y, Ogata A, Koyama M, Inoue T.
An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS. PLoS One. 2010 Dec 9;5(12):e15307. doi: 10.1371/journal.pone.0015307. Shimazawa M, Tanaka H, Ito Y, Morimoto N, Tsuruma K, Kadokura M, Tamura S, Inoue T, Yamada M, Takahashi H, Warita H, Aoki M, Hara H.
Phosphodiesterase 7A inhibitor ASB16165 impairs proliferation of keratinocytes in vitro and in vivo. Eur J Pharmacol. 2010 May 10;633(1-3):93-7. doi: 10.1016/j.ejphar.2010.01.024. Epub 2010 Feb 2. Goto M, Kadoshima-Yamaoka K, Murakawa M, Yoshioka R, Tanaka Y, Inoue H, Murafuji H, Kanki S, Hayashi Y, Nagahira K, Ogata A, Nakatsuka T, Fukuda Y.
A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide. Biochem Pharmacol. 2010 May 15;79(10):1437-44. doi: 10.1016/j.bcp.2010.01.010. Epub 2010 Jan 21 Uchida H, Kondoh M, Hanada T, Takahashi A, Hamakubo T, Yagi K.